Acute and Chronic Rhinosinusitis
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The Clinical Investigation is a peer-reviewed, open-access academic journal that provides worldwide distribution of original, distinctive scientific publications based on the many fields of clinical and clinical medicine to discuss a variety of brand-new challenges in Clinical investigation.
Recently In our previous issue we have published article entitled "Treating Acute and Chronic Rhinosinusitis in Children using an Osmotic, Nasal Surface Cleaning, Non-Medicated Polymeric Film" by one of the eminent author "Dr. Rémi Shrivastava" Vitrobio Research Institute, ZAC de Lavaur, Issoire, France.
This article is about "Treating Acute and Chronic Rhinosinusitis in Children using an Osmotic, Nasal Surface Cleaning, Non-Medicated Polymeric Film" One of the most prevalent diseases in children is acute and chronic rhinosinusitis, which has a significant impact on both children's and parents' quality of life. The physiopathology is complex and includes sinus drainage obstruction brought on by bacterial biofilm on sinus apertures, nasal mucosa irritation, and cellular damage. There are currently no multi-target treatments available, and no method has been found to unblock and drain obstructed sinuses. For the treatment of pediatric rhinosinusitis, we assessed the clinical efficacy of a new generation of multi-target, non-irritant, osmotic, safe, polymeric glycerol film.
20 kids were divided into a test product group and 10 kids were divided into a saline solution comparison group for the duration of the 15-day, randomized, placebo-controlled, double-blind clinical trial on efficacy and safety. The children had a baseline rhinosinusitis symptom severity score of >25/50 and ranged in age from 3 to 16 years. During a period of 15 days, 2 to 3 nasal sprays were administered 3 to 4 times per day. At baseline, two hours after the first treatment, and on days one, three, six, and fifteen (visits one through three), effects on rhinorrhea or congestion, fever, cough, sleep, and face pain were noted (visit 4). Also noted were the necessity for antibiotics and any negative effects.
The use of a topical multi-target, instant nose cleaning, non-irritant, topically applicable, and safe filmogen solution can be considered a breakthrough for the treatment of children's rhinosinusitis in the absence of any treatment to open and drain the sinuses and act on multiple factors involved in the condition.
Problems
Inflammatory disorders of the paranasal sinuses and lining of the nasal mucosa (NM), rhinosinusitis (RSS) and chronic rhinosinusitis (CRSS), collectively referred to as rhinosinusitis (RS), affect more than 14% of adults and children. Although it occasionally has bacterial, fungal, or allergic causes, the illness typically begins as a viral infection after a cold caused by influenza, parainfluenza, rhinoviruses, or coronaviruses. Millions of free viral particles are released on the NM surface as a result of the initial intracellular virus development, which kills cells.
The physiopathology of RSS and CRSS in children demonstrates that it is a complex condition that can only be effectively treated with a multi-target approach. Due to the limited vascularization of the sinus cavities, no medication or antibiotic can effectively reach the sinuses, making treatment very challenging.
Since RS is a multi-factorial disease, current treatments for it include single target-oriented medical or surgical therapy, but to reduce the concentration of surface pathogens and contaminants, the medical therapy frequently calls for combining multiple medications, such as antibiotics, topical nasal steroids, and/or oral steroids, as well as saline or sea water irrigation.
The Nesospray-Kid (TP) versus 0.9% NaCl saline solution (CP) comparison study was designed as a comparative, randomised, double-blind, parallel-group, observational clinical trial to assess the efficacy and safety of the Nesospray-Kid (TP) versus CP for the treatment of acute or chronic rhinosinusitis in children. The nasal surface of 20 children in the TP group and 10 children in the CP group received 3 to 4 sprays, every 30 minutes during the first 2 hours of treatment, and 3 to 4 times daily afterwards for up to 15 days. Since saline solution (0.9%) shares many characteristics with the TP, it was chosen as a comparison product.
Results
If the patient's condition does not improve or worsen during the course of the trial, investigators may administer antibiotics for ethical considerations. Four out of ten children in the CP group received short-term antibiotics; however, no child in the TP group required antibiotic treatment since their recovery was stronger and quicker than with CP treatment. These findings suggest that in children with RSS, TP helps reduce the requirement for antibiotic treatment.
Children's rhinosinusitis is a multifactorial, acute or chronic condition that can involve viral, bacterial, and/or inflammatory nasal mucosa as well as obstructed sinus passages, which can cause excruciating facial agony. Several chemical treatments with different adverse effects are presently employed to treat this condition because no medication can address all of the contributing elements at once. According to the clinical efficacy and safety findings provided in this study, treating rhinosinusitis in children using an external and topical strategy that involves maintaining a clean nasal surface and applying osmotic pressure to open the sinuses is extremely effective, multi-target, and safe.
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