Journal of Clinical Genetics and Genomics

Understanding the fundamental causes of inherited illnesses and genetic disorders, including Fragile X syndrome, thalassemia, Huntington's disease, cystic fibrosis, down syndrome, mitochondrial disease, muscular dystrophy, and Patau syndrome, is a priority for the Journal of Environmental Microbiology. Studies that use molecular methods to examine illness causation are given particular attention. The article encourages related research on gene therapy to find viable treatments for the disease.

Studies using genomic methods, including RNA-Sequencing, ChIP-Sequencing, microarrays, and genetic mapping utilizing next-generation sequencing technology, are strongly advised. Studies looking for mutations or discovering polymorphisms using diagnostic techniques like RAPD and RFLP are also recommended. Articles on the subjects of neurogenetics, cancer genetics, medical genetics, biochemical genetics, population genetics, genetic epidemiology, and immunogenetics are also covered by the Journal of Clinical Genetics and Genomics.

The Journal of Clinical Genetics and Genomics is taking part in the Fast Editorial Execution and Review Process (FEE-Review Process) with an additional prepayment of $99 on top of the usual article processing fee. Fast Editorial Execution and Review Process is a special service that enables the handling editor to respond to the article more quickly during the pre-review phase and to provide a review. After submission, pre-reviews can be finished in as little as 3 days, and reviewer reviews can take up to 5 days. After that, publication and revisions can be finished in as little as two days. The previous reviewer will have an additional 5 days to conduct an external review if the handling editor flags the article for revision.

JOURNAL HIGHLIGHTS

Genes assort independently when they are on different chromosomes or when they are located relatively widely apart on the same chromosome. In other words, the allele received for one gene does not affect the allele received for the other when the genes are incorporated into gametes. This leads to the creation of all 444 potential forms of gametes with equal, or 25%25%25 percent, frequency in a double heterozygous organism (AaBb). How is this possible? Because homologous chromosome pairs during meiosis are oriented at random, genes on different chromosomes assort separately. The paired chromosomes known as homologous chromosomes contain identical genes but may have various alleles of those genes. Each homologous pair has a parent from the organism's mother and a parent from its father.

The homologues of each pair separate at the first stage of meiosis, as shown in the diagram below. Each pair's "dad" and "mom" chromosomes are randomly assigned to a side throughout this procedure. When two genes are regulated, four different types of gametes are produced equally frequently.

Due to cross-over, genes that are on the same chromosome but located far apart assort independently. This is a process where homologous chromosomes randomly exchange matching fragments at the start of meiosis. New alleles can be combined by crossing over onto the same chromosome, resulting in them entering the same gamete.

We can now see that different gamete types are present in extremely different numbers. The parental configurations of alleles, or those that were present on the chromosome in the organism before meiosis, are present in the common types of gametes.

(i.e., on the chromosome it got from its parents). Recombinant allele configurations, or those that can only develop if a recombination event (crossover) occurs between the genes, are seen in the rare forms of gametes.

What makes recombinant gamete types uncommon? The fundamental explanation is that gene crossovers between closely related genes are uncommon.

Important details:

Genes are referred to as unlinked when they are located on distinct chromosomes or far apart on the same chromosome.

Genes are referred to as linked when they are located close to one another on the same chromosome. This means that the alleles, or gene variants, that are already present on one chromosome will most likely be inherited together.

By calculating the recombination frequency using information from genetic crosses, we may determine whether and how closely two genes are connected.

Making linkage maps, which display the arrangement and relative locations of the genes on the chromosome, requires finding the recombination frequencies for numerous gene pairs.

MANUSCRIPT SUBMISSION:

Each manuscript that is submitted is processed for an initial quality control check by the editorial office before going through the external peer review procedure. Preliminary quality control typically concludes in 7 days and focuses mostly on English, journal scope, and journal formatting.

Submission Link: https://www.pulsus.com/journal-clinical-genetics-genomics.html

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