Journal Series

A very limited number of small molecule inhibitors targeting PD1/PDL1 signaling pathways have entered clinical trials at this point. We investigated several ligand databases against PD1 and PDL1 separately to evaluate their prospects as potential small molecule PD1/PDL1 inhibitors. Computational studies showed promising results for our hit compounds and some of which are commercially available as well. Three potential small molecule inhibitors for each of PD1 and PDL1 enzymes have been identified based on our structure-based virtual screening of ZINC15 ligand database. Protein-ligand interactions between our hit compounds and their corresponding target receptors have been analyzed using relevant software which indicates significant binding affinity due formation of hydrogen bonds and van der Waals interactions. Predicted ADME properties of all hit compounds have also been determined using online tools. In addition, molecular dynamics simulation has also been performed at one nanosecond

Introduction Dental implants are an increasingly popular treatment for missing teeth. And it’s no wonder – they offer several benefits over other dental treatments, such as dentures and bridges. Dental implants are titanium posts that are surgically placed in your jawbone to serve as a replacement for your natural teeth. They are a permanent solution to tooth loss and can give you back your smile. Dental implants are strong and durable, and they look and feel like your natural teeth. They are also easy to care for – you just brush and floss them like your regular teeth. If you are considering dental implants, then this comprehensive guide is for you. Keep reading to learn everything you need to know about dental implants, including the benefits, risks, and costs. Benefits of Dental Implants Improved Appearance Dental implants are designed to look, feel, and function like your natural teeth. They are custom-made to match the color, shape, and size of your existing teeth, ensuring a seam

In this blog post, we'll share some valuable tips and tricks on how to boost your manuscript submissions and attract the best minds in histology research. So grab your notebook and get ready to master the art of attracting scientists! Introduction to Histology Journals Histology journals are a type of scientific journal that focuses on the study of tissues and cells. The field of histology is important for understanding the structure and function of organs and organ systems. Histology journals publish original research articles, reviews, case reports, and other types of articles related to the study of tissues and cells. There are many histology journals available, each with its own focus and audience. Some histology journals are geared toward basic research while others are more clinically oriented. It is important to choose the right journal for your manuscript. When submitting a manuscript to a histology journal, be sure to read the instructions for authors carefully. Each jour

Introduction The field of electrochemistry has seen significant advances in recent years, with new technologies and applications being developed at a rapid pace. In order to keep up with the latest developments in the field, it is important to read and review the latest journal research.  There are many journals that publish research in electrochemistry, but not all of them are created equal. Some journals are more reputable than others, and some are more specialized. In order to choose the right journal for your needs, it is important to know the different types of journals that exist.  This article provides an overview of the different types of electrochemistry journals, as well as the benefits and drawbacks of each. The field of electrochemistry includes the study of the production of electricity from chemical reactions and the use of electrical energy to bring about chemical reactions. It covers a wide range of topics, from the corrosion of metals to the behavior of semiconductors

Overview The peer-reviewed, open-access Journal of Environmental Chemistry and Toxicology publishes original research and review articles on all facets of the scientific investigation of environmental chemical and biochemical processes. It is the study of how biological and human activity affects chemical species in the air, soil, and water environments, as well as their sources, processes, motions, results, and fates. chemical species in the surroundings of the air, soil, and water; and how human activities and biological activity affect these. Environmental toxicology is a multidisciplinary branch of research that examines how different chemical, biological, and physical agents harm living things. The Journal publishes papers on a variety of topics related to the chemistry of the environment (air, water, soil, sediments, space, and biota), such as atmospheric chemistry, soil chemistry, climate change, marine chemistry, water chemistry, polar chemistry, fire chemistry, iatrochemistry

A new research article, curated by Dr. Naval Kishor Lodha , Dr. Biram Chand Mewara and Dr. Krishna Murari and titled “ Cohort Study of Communication Skills in Medical Sciences ”, has been published. Introduction “The art of medicine is intricately tied to the art of communication.” “Medicine is an artist whose magic and creative ability have long been recognized as residing in the interpersonal aspects of patient-physician relationship”. In traditional medical curricula, communication is not taught formally. Aim and Objectives To study the perception of medical students about the usefulness of the communication skills lab. The perception of medical students about the use of communication skills lab. Materials and Methods This observational study was carried out at the Communication Skills Medical Lab of Medical College. Feedback was obtained with the help of a prevalidated questionnaire from 100 final DMLT students about their perception of the utility of the module taught in the Com

Abstract Two three-dimensional surface technologies close-range photogrammetry and optical surface scanning have lately evolved into procedures that are more versatile, less expensive, and more precise. Yet, the promise of these techniques has not yet been completely realized in the routine of forensic post-mortem inquiry. In the present investigation, we contrasted the performance of stereophotogrammetry-based Vectra H11, a portable handheld surface scanner, and digital camera-based photogrammetry coupled with industry-standard Agisoft PhotoScan1 software. A 25-year-old woman who was still alive and two 63-year-old male forensic cases who had been admitted for post-mortem examination at the Department of Forensic Medicine in Hradec Králové, Czech Republic, were the subjects of the study. One of the men had died from traumatic, self-inflicted injuries (suicide by hanging), and the other had been diagnosed with heart failure. All three examples were captured simultaneously using a Niko

If you're in need of a dental implant, you may have heard the term "bone grafting" thrown around by your dentist or oral surgeon. But what exactly is bone grafting, and how does it work? In this article, we'll provide an overview of bone grafting, including its uses, benefits, and the different types of bone grafts available. Bone grafting is a surgical procedure used to repair or replace bone that has been damaged or lost due to injury, disease, or tooth loss. It involves taking bone from one part of the body (known as the donor site) and transplanting it to the area in need of repair (known as the recipient site). The transplanted bone then serves as a scaffold for new bone growth, helping to regenerate and strengthen the area over time. Types of Bone Grafting There are several different types of bone grafts available, including autografts (where the bone is taken from the patient's own body), allografts (where the bone is taken from a donor), and synthetic bone

An international scientific journal called Journal of Neuroscience and Neuropharmacology publishes high-quality articles on a variety of topics, including molecular diseases, neuroendocrinology, neurotoxicology, intracellular inflammation, neurodegenerative diseases, sensory transduction, neural processing, and gene regulation and genetics. Introduction Choosing behavior necessitates balancing a variety of decision factors, such as utility, uncertainty, delay, or effort, which work together to define a subjective value for each option or course of action that is being examined. This ability is based on prior knowledge of the rewards (and penalties) that could arise from previous actions. Making judgements in a social setting may require strategic consideration of other people's goals and how their actions may affect one's own results. Other emotions have an impact on valuation as well. These emotions help us adaptively control our decisions so that we can, for instance, avoid

Clinical Psychiatry and Neuroscience : An open access journal focuses on the study of scientific research on mental illnesses like schizophrenia, autism, ADHD, major depressive disorder, obsessive-compulsive disorder, and adjustment disorder. Other conditions covered include Alzheimer's disease, Parkinson's disease, Huntington's disease, Parkinson's disease, and Parkinson's disease. The Journal is dedicated to providing its examiners around the world with the most recent knowledge regarding mental illnesses and psychotherapy drugs. In the upcoming issue we are going to publish a review article entitled: Types of depression, written by Gudisa Bereda, Department of Pharmacy, Negelle Health Science College, Guji, Ethiopia. There were lights on for depression in this great piece of writing. A common psychiatric condition, depression affects 10% of people in the general population over their lifetime. Postnatal depression, also known as postpartum depression, is a type o

Abstract For the past 200 years, the animal-human interface has been a key factor in the development of vaccination. The pathogen of interest was grown, attenuated, inactivated, and fractionated to create many conventional veterinary vaccinations. Although these strategies have been quite effective, we have come to the point where they have mostly been used up and new strategies are needed. The functionality of subunit vaccines has also, until very recently, been largely restricted to diseases that can be controlled by humoral immunity, despite the fact that they have improved safety profiles and created opportunities for combined discrimination between vaccinated and infected animal (DIVA) approaches. Introduction The field of vaccineology has its roots in a sequence of empirical findings and technological advancements that have gradually altered how vaccines are created and administered in order to prevent and treat disease. From Edward Jenner's use of cowpox as a vaccine for hum

Overview Osteology is the study, characterization, and examination of bones, as well as their structures and purposes. Osteology is divided into two primary categories: human and animal. Human Osteology There are 206 bones in the human body, and they can be divided into four different categories based on how they are shaped: long bones, short bones, flat bones, and irregular bones. Compact bone, which is located on the surface of bones and is solid and dense, and spongy bone, which is porous and found inside of bones, are two different types of tissues that make up bones. Bones have several functions, which include: Serving as a framework to hold the body up and safeguard our internal organs, such as the heart and lungs. Our bones also have ligaments, tendons, and muscles that help us move. Generating platelets and blood cells, which are essential for the production of new blood and the healing of wounds. Storing energy reserves like lipids as well as minerals like calcium and phosphor

Overview Simply by glancing at your teeth, a dentist may learn a lot about your health and everyday routine. But did you know that archaeologists have found that teeth contain a lot more data than previously thought? By examining the chemical makeup of teeth, we can learn what kinds of food a person consumed as well as the location of the food's origin. Even in the absence of written records, the movements and diets of humans can be reconstructed from teeth found in archaeological sites using a technique called isotope analysis. In this post, we'll talk about the materials that make up our teeth and how isotope analysis can be used to study ancient individuals. Consider the differences between a cow's teeth and those of a lion. Long and razor-sharp, lion teeth are designed for grabbing prey and slicing through meat. Large and flat, cow teeth are ideal for eating plant matter. The animals' teeth provide information on the kinds of food they consume and how they chew it.

Cardiovascular disease is a becoming major cause of death around the world. It explains a group of conditions that create problems in the heart and blood vessels, with coronary artery disease, heart failure, stroke, and many more. There are factors of risk which include genetics and age, and lifestyle choices like diet and exercise which plays a significant role in its development. In this blog, we'll go deep down and find more about this and strategies for prevention also. The most common risk factor for cardiovascular disease is high blood pressure or maybe hypertension. High blood pressure can create problems in the arteries, which can lead to heart attack and stroke. Also, there are more like smoking, high cholesterol, diabetes, and obesity. These risk factors can often be controlled through lifestyle changes, like physical activity, quitting smoking, and consuming a healthy diet. Physical exercise on regular basis like gym, running, etc. is an essential part of Cardiovascular

Overview That hundreds of millions of people lack access to clean drinking water on a planet with a surface that is largely covered by water is a harsh paradox. Arsenic is a plentiful and hazardous metal found in large quantities in the earth's crust, and it is one of the main causes of the contamination of drinkable and natural water sources. In more than 100 countries, arsenic is currently thought to be the main contributor to contaminated groundwater. It is also a known source of serious illnesses, particularly in underdeveloped nations, where the population is more vulnerable. Methods for detecting arsenic in soil, food, and water are therefore required to be effective and trustworthy. The Premise of the Arsenic Test Principle: The limit test for arsenic is based on the reaction between arsenic gas and hydrogen ions, which results in the formation of a yellow stain on mercuric chloride paper when reducing agents like potassium iodide are present. The exam, also known as the Gut

Overview Meningitis is a potentially life-threatening condition that occurs when the protective membranes surrounding the brain and spinal cord become inflamed. This inflammation can be caused by a variety of infectious agents, including bacteria, viruses, fungi, and parasites. In this article, we will discuss the symptoms, causes, treatment, and prevention of meningitis. Symptoms of Meningitis The symptoms of meningitis can vary depending on the age and health of the affected individual, as well as the underlying cause of the infection. Some of the most common symptoms of meningitis include: Headache Stiff neck High fever Nausea and vomiting Sensitivity to light Confusion or altered mental status Seizures Skin rash In newborns and infants, symptoms of meningitis can also include: Poor feeding Irritability Lethargy Bulging Fontanelle (the soft spot on the top of the head) Because meningitis can progress rapidly, it is important to seek medical attention as soon as possible if you or so

Overview Osteosarcoma is an aggressive form of bone cancer that can form in children and newly adults. It is generate by the increase of malignant cells in the bones, generally in the long bones of the legs and arms. Cause of this disease is not fully known, factors such as genetics and previous exposure to radiation or chemotherapy may leads the risk of developing this in body. In this Blog, we will discuss the Symptoms of Osteosarcoma Diagnosis of Osteosarcoma Treatment of Osteosarcoma Symptoms of Osteosarcoma First symptoms is likely begin from the tumor. Pain is the common symptom of Osteosarcoma, which can leads spread to other body parts also. Other may include swelling, less motion, and a lump or mass in the area which is affected. Sometime, the tumor can make the bone weak, which can make fracture. Diagnosis of Osteosarcoma Doctor will generally perform physical exam, look out the patient's medical history, and arrange imaging tests which include X-rays, CT scans, and MRI s

Overview We are fashioned by our thoughts, and we become what we think, the Buddha said in the Dhammapada. This idea emphasizes the significant impact that our thoughts have on the experiences and lives that we lead. Buddhism teaches that depending on our capacity to regulate the mind, it can either be a friend or an enemy. When left unchecked, the mind might become restless and prone to feelings of revolving ideas. The Buddhist way includes developing awareness and techniques for calming the mind and fostering inner tranquilly. The term "monkey mind" has its roots in an old Chinese folktale, and it is recounted in the famous book Journey to the West by Wu Cheng'en, a poet from the Ming Dynasty. Sun Wukong, sometimes known as "The Monkey King," is the primary character and a mischievous trickster. Sun Wukong embarks on a voyage to India in the book in pursuit of Buddhist texts and enlightenment. He gains control over his monkey mind along the road by meditating